[Vuejs]-Disable selected option from select using vue

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There’s no need to add a custom method, you can work with v-model and the data you already have.
Add a :disabled='modalIU.inpIdSpecialitate === item.inpIdSpecialitate' on the option with the v-for, so you conditionally disable the option if it is the one currently selected.
You can then remove the v-on:change="disableEnable()". Also consider adding a :key attribute to your v-for for best practice.

[Vuejs]-Vue.js How to use <template v-slot> on Props

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I just created a codesandbox example for this functionality, I added a disabled property for each option, and on change event listner, I get the option index, and make it disabled.

https://codesandbox.io/s/elated-smoke-lwcriw?file=/src/components/DisabledOptionOnSelect.vue:351-513