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Yes, it’s possible to develop a whole website/web app without an extra framework like express. The thing is that you have to manage so many things on your own.
Your web app/website code became harder to read as you progress in NodeJS. URL routing is complex than express. So, You have to write a bunch of switch cases.
It’s possible to use NodeJS alone. But, you have to write more code that is provided by express or any other framework.
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Source:stackexchange.com